POLYMER CLASS: Polyanhydrides: COMMON NAMES: Sebacic acid polyanhydride, Poly(sebacic anhydride) STRUCTURE BASED NAME: Poly(oxydecanedioyl) ACRONYMS: CAS # The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). Sebazinsaeure . Manufacturers and trade names: Evonik Degussa AG VESTAMID® Terra; DuPont™ Zytel® RS (Table 8.39). sebacic acid: ChEBI ID CHEBI:41865: Definition An α,ω-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. Sebacic Acid. Since these monomers have comparatively low molecular weight (Mn = ~500–1000) and crosslinking occurs only at the chain ends, their crosslinked network has higher crosslinking density and thus higher mechanical properties than most injectable materials. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. In its pure state, it is a white flake or powdered crystal. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. In addition, it can be confirmed that the crystal size is different depending on whether the sebacic acid-structured dicarboxylic acid group is added or not. 925-83-7. Our product Sebacic Acid is REACH registered under the following reference number: 01-2119519212-52-0000. Robert Langer, in Advances in Chemical Engineering, 1994. This category of injectable material includes low molecular weight monomers that are synthesized by reacting diacids, such as sebacic acid (SA), 1,3–bis(carboxyphenoxy) propane (CPP) and 1,6–bis(carboxyphenoxy) hexane (MCPH) with methacrylic anhydride (Burkoth and Anseth, 2000; Burkoth et al., 2000) (Fig. Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. [from Leong, K. W., Brott, B. C., and Langer, R., J. Find Sebacic Acid at SpectrumChemical.com now. Technically speaking, PA1010 occupies a position between the high-performance long-chain polyamides such as PA12 and PA1212 and the standard polyamides PA6 and PA66, which have shorter chain lengths. It is a white flake or powdered solid. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). More hydrophobic polymers, PCPP and PCPP-SA 85:15, displayed constant erosion kinetics over eight months. The polymer has a melting point of around 216 °C and a low water absorption of around 1–1.2% at 21 °C and 65% RH, which gives it better dimensional stability and electrical properties than nylon 6 and nylon 6.6.It is a commercially important polymer and is often used in place of nylon 6 and nylon 6.6 in engineering plastics applications. Details of dossier compliance checks and testing proposal evaluation. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Public (risk management) activities co-ordination table. Guidance on safe use - recommendations by substance registrant on the proper use of the substance in various situations. Compared to most biomaterials which possess bulk degradation profiles (surface and interior degrade nearly simultaneously), polyanhydrides degrade with a surface–erosion profile (degradation occurs layer by layer from the surface) due to their high hydrophobicity. Articles of Sebacic acid are included as well. The realm of aliphatic-aromatic copolyesters based on PET expanded far beyond succinic acid with the use of several other renewable-based comonomers, including C6 adipic acid [60] or C10 sebacic acid [61,62], or other diacids possessing a double bond in their backbone, like the case of maleic acid (or its maleic anhydride derivative) [34,63], or mixtures of the above comonomers [64], among others [111,112]. Stars This entity has been manually annotated by … The Chemical Structure of Sebacic Acid Sebacic Acid is a castor-derived fatty acid and a precursor to various esters such as dioctyl sebacate , dibutyl sebacate , and dimethyl sebcate . Manufacturing, properties and tensile failure of nylon fibres, Handbook of Tensile Properties of Textile and Technical Fibres, Nylon 610 is produced by the reaction of hexamethylenediamine with, Polymer Science: A Comprehensive Reference, The general structure of anhydride monomers used for photopolymerizations consists of a repeating hydrophobic core molecule such as, Improving mechanical properties of injectable polymers and composites, This category of injectable material includes low molecular weight monomers that are synthesized by reacting diacids, such as, Film Properties of Plastics and Elastomers (Third Edition), Polyamide 1010 is the polycondensation product of 1,10-decamethylene diamine and 1,10-decanedioic acid (, Glucose Transporter 4 Translocation Activators From Nature, Discovery and Development of Antidiabetic Agents from Natural Products. Molecular structure. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. The molecular structure is based on structures generated from information available in ECHA’s databases. demonstrated that eicosapentaenoic acid (15)-enriched phosphatidylcholine from sea cucumber Cucumaria frondosa significantly promotes the protein expression of GLUT4 in skeletal muscle cells (Hu et al., 2014b, p. 457). Polyethylene Terephthalate: Copolyesters, Composites, and Renewable Alternatives, Andreia F. Sousa, ... Jorge F.J. Coelho, in, Poly(Ethylene Terephthalate) Based Blends, Composites and Nanocomposites. Chemsrc provides Sebacic acid(CAS#:111-20-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Figure 8.24. Other release to the environment of this substance is likely to occur from: indoor use (e.g. Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release. It is resolved in ethanol, ether and soluble slightly in water. Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, FCM and Articles Regulation, Annex I - Authorised Substances, Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. We manufacture and distribute fine chemicals and laboratory products - with quality and delivery you can count on every time. This is unique source of information on the chemicals manufactured and imported in Europe. Azelaic acid is made by the ozonolysis of another natural product, oleic acid: Sebacic acid is used for nylon 610 and azelaic acid for nylon 69. PBT-co-PBA, commercialized by BASF under the trade name ecoflex® [108], is today one of the most successful biodegradable aliphatic-aromatic polymers, opening identical prospects for other similar products (Figure 7.3). The molecular structure is based on structures generated from information available in ECHA’s databases. Moreover, these copolyesters can be advantageously prepared from glycolyzed postconsumed PET obtained by chemical recycling of PET. The report analyzes, tracks, and presents the worldwide market size of the leading players in each region around … This section is based on three sources for information (harmonised classification and labelling (CLH), REACH registrations and CLP notifications). Other relevant information includes the following: To see the full list of notified classifications and to get more information on impurities and additives relevant to classification please consult the C&L Inventory. Decanedihydrazide. This enables these materials to maintain > 70% of their tensile modulus and their architectural integrity at 50% mass loss (Muggli et al., 1999). 1,10-Decanedioic acid; Sebacic acid; Octadecanedioic acid Docosanedioic acid azelaic acid, dipotassium salt tin(ii)dodecanoate ZINC PALMITATE 15-Bromopentadecanoic acid 12-Sulfanyldodecanoic acid ... ChemWindow structure drawing, spectral analysis, and more. Burdick, in Polymer Science: A Comprehensive Reference, 2012, The general structure of anhydride monomers used for photopolymerizations consists of a repeating hydrophobic core molecule such as sebacic acid, carboxyphenoxy propane, or carboxyphenoxy hexane with photoreactive methacrylate end groups. The information is aggregated from the data coming from REACH substance registrations provided by industry. Sebacic acid 99% Synonym: Decanedioic acid CAS Number 111-20-6. An increase of 800 times was observed when the sebacic acid concentration reached 80%. Therefore, methacrylated CPP has higher molecular weight than methacrylated SA. In its pure state it is a white flake or powdered crystal.Sebacic acid is produced from castor oil by using sodium hydroxide, sulfuric acid with catalysts including zinc oxide and phenol.In the industrial setting, sebacic acid and its This substance can be found in products with material based on: plastic (e.g. This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The investigation of Puangsansuk et al. Sebacic acid is a normal urinary acid. Another interesting compound phytanic acid (14) (Fig. The EC or list number is the primary substance identifier used by ECHA. Fatty acids, C18-unsatd., dimers, polymers with ethylenediamine, piperazine and sebacic acid Valid: 01/15/2010: Active 2020 CDR Full Exempt Fatty acids, C18-unsatd., dimers, polymers with ethylenediamine, piperazine and sebacic acid Unknown: Active 2020 CDR TSCA Inv Active sebacic acid, compound with hexane-1,6-diamine (1:1) Pre-Registration process . The castor oil is treated with caustic soda at high temperature, for example 250 °C, so that saponification, leading to the formation of ricinoleic acid, is followed by a reaction giving sebacic acid and octan-2-ol: Because of the by-products formed, the yield of sebacic acid is necessarily low, and in practice, yields of 50–55% (based on the castor oil) are considered to be good. The degradation rates were enhanced by copolymerization with. FIg. The sebacic acid market is expected to grow by USD 129.57 million during 2020-2024, according to Technavio. Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and for thermoplastic manufacture. This site is not fully supported in Internet Explorer 7 (and earlier versions). The castor oil is treated with caustic soda at high temperature, e.g. Polyester polyols for urethane and related polymer foams include: (a) aliphatic polyesters prepared by the reaction of dibasic acids, such as adipic acid, phthalic acid, and sebacic acid, with glycols such as ethylene glycol, propylene glycol, diethylene glycol, 1,4–butanediol and 1,6–hexanediol; (b) aliphatic polyesters prepared by the ring–opening polymerization of lactones, e.g., epsilon–caprolactone; and (c) aromatic polyesters prepared by the transesterification of reclaimed polyethylene terephthalate or distillation residues of dimethylterephthalate. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. Such UPR resins are widely used in a variety of products [34], such as in coating, building, and construction materials, as well as in automotive and aircraft applications, among others. The date of the last update corresponds to the publication date of the InfoCard and not necessarily to the date in which the update occurred in the source data. Stars This entity has been manually annotated by … Additional Metadata. In its pure state it is a white flake or powdered crystal. A new family of ricinoleic acid based polyesters was synthesized using catalyst free melt-condensation polymerization with sebacic acid, citric acid, mannitol and ricinoleic acid as precursors. Other identifiers . Multifunctional anhydride-based monomers and oligomers were first synthesized for materials with enhanced mechanical properties for bone tissue engineering.195 The extreme hydrophobicity of the polymer backbone, along with high cross-linking densities, prevents bulk degradation of the polymer. PubChem Substance ID 24857096. The first step consists in the depolymerization reaction of PET wastes with an adequate glycol, most usually 1,3-propanediol and a catalyst like zinc acetate, or the more environmentally friendly sodium carbonate; followed by polytransesterification reaction between the recovered PET monomers, maleic anhydride, and also in some cases using other dicarboxylic acids (e.g., succinic acid and adipic acid) in order to modulate the properties of the UPR resins especially in terms of hardness [64]. More information about CAS and the CAS registry can be found here. A new family of ricinoleic acid based polyesters was synthesized using catalyst free melt-condensation polymerization with sebacic acid, citric acid, mannitol and ricinoleic acid as precursors. The molecular structure is based on structures generated from information available in ECHA’s databases. The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. Some substance identifiers may have been claimed confidential, or may not have been provided, and therefore not be displayed. It absorbs little water and as a result its mechanical properties and high dimensional stability change little when exposed to fluctuating environmental humidity. Sebacic acid dihydrazide. Despite its crystallinity, PA1010 can be used to manufacture films with good transparency compared to other semicrystalline polyamides. In that case, the ATP (Adaptation to Technical Progress) number is displayed. sebacic acid, compound with hexane-1,6-diamine (1:1) Pre-Registration process . REACH registration dossiers have greater data requirements (such as supporting studies) than do notifications under CLP. By altering the CPP/SA ratio, nearly any degradation rate between 1 day and 3 years could be achieved (25) (Fig. Electrolysis of the potassium salt of monomethyl adipate in a mixture of methanol and water gives dimethyl sebacate. 4.3), a C-20 chain fatty acid, has also been evaluated to promote the acquisition of the brown adipocyte morphology, thereby facilitating a coordinate induction of the mRNAs for GLUT4 gene markers of brown adipocyte differentiation (Schluter et al., 2002, pp. We synthesized and evaluated biodegradable and elastomeric polyesters (poly(glycerol sebacate) (PGS)) using polycondensation between glycerol and sebacic acid to form a cross-linked network structure without using exogenous catalysts. S.K. In another study, Hu et al. If generated, an InChI string will also be generated and made available for searching. Use descriptors are adapted from ECHA guidance to improve readability and may not correspond textually to descriptor codes described in Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment. If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. Molecular Weight 202.25 . SEBACIC ACID 97AN39ICTC Overview Structure Names 7: Classification 1: Identifiers 10: Relationships 2: Active Moiety 1: Notes 2: Audit Info References 17: Moieties 1: Substance Class: Chemical Record UNII: 97AN39ICTC. Sebacohydrazide. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH 2) 8 (CO 2 H) 2. Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. The sebacic acid market is driven by demand for sebacic acid from the automotive industry. According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified. This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers. Molecular structure. Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. Sebacic acid is a naturally occurring dicarboxylic acid with the structure (CH₂)₈. PA1010 is semicrystalline, which is the reason for its high mechanical resistance and chemical stability. Sebacic acid is a naturally occurring dicarboxylic acid with the structure (HOOC)(CH2)8(COOH). Brydson, in Plastics Materials (Seventh Edition), 1999. Sebacic Acid All mass spectra in this site (plus many more) are available from the NIST/EPA/NIH Mass Spectral Library. Sebacic acid is a normal urinary acid. Linear Formula HO 2 C(CH 2) 8 CO 2 H . gloves, shoes, purses, furniture). sebacic acid: ChEBI ID CHEBI:41865: Definition An α,ω-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. [64] on UPR resins led to the development of novel materials with improved impact strength due to the incorporation of saturated acids, especially adipic acid, and the consequent lower cross-linking density in comparison to typical resins without saturated acids in their backbone. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. (a) Flexible packaging film; (b) coated paper cup; and (c) packaging film [114]. Oleris ® Sebacic acid is widely used to produce a salt derivative, the (di)sodium sebacate, which is a corrosion inhibitor. Sebacic acid 99% Synonym: Decanedioic acid CAS Number 111-20-6. Mukhopadhyay, in Handbook of Tensile Properties of Textile and Technical Fibres, 2009. PubChem Substance ID 24857096. Chapman J(1), Regan F. Author information: (1)Marine and Environmental Sensing Technology Hub, National Centre for Sensor Research, School of Chemical Sciences Dublin City University, Ireland. Overall yields are reported to be about 85% (Castor Oil, 2015). the products in which the substance may be used) may refer to uses as intermediate and under controlled conditions, for which there is no consumer exposure. Molecular structure. 58 / Monday, March 26, 2012 / Rules and Regulations 10/12/2015 EN (English US) 3/5 The sebacic acid market is driven by demand for sebacic acid from the automotive industry. A substance may have its use restricted to certain articles or products and therefore not all the examples may apply to the specific substance. MDL number MFCD00004440. Sebacic acid is a naturally occurring di-carboxylic acid primarily derived from castor oil with the structure (HOOC) (CH2)8 (COOH). Benzimidazole salt of sebacic acid, a new proton conductor from the family of benzimidazole compounds of dicarboxylic acids, was crystallized to search for the factors which determine the hydrogen bond motif and the structure of the crystals. Besides the superior mechanical properties discussed above, the polyanhydride–based materials are also highly osteo–compatible (Anseth et al., 1999; Poshusta et al., 2003), which makes them suitable for orthopedic applications, particularly as load–bearing scaffolds. Synonyms. Sebacic acid is also a raw material to produce sebacate diesters (DOS, DBS, …), used in complexed greases or lubricants. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD), also known as glutaric aciduria type II (GAII), a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. Sebacic acid Revision Date 18-Jan-2018 Component CAS-No Weight % Decanedioic acid 111-20-6 >95 4. You have no items in your cart. Oligomerization can occur during the synthesis of the methacrylated monomer, and oligomerization occurs to a greater extent during the methacrylated CPP synthesis. In terms of thermal stability, thermogravimetric analysis results showed that UPR were typically stable up to 300°C [34,64]. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. 111-20-6 . Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its … Instead, polyanhydrides degrade via hydrolysis of anhydride groups in a controlled fashion through surface erosion, while maintaining their structural integrity throughout the degradation process (> 70% of their tensile modulus with 50% mass loss).196, Y. Qiu, ... J. Temenoff, in Injectable Biomaterials, 2011. This substance is used in the following areas: formulation of mixtures and/or re-packaging. If no EU harmonised classification and labelling exists and the substance was not registered under REACH, information derived from classification and labelling (C&L) notifications to ECHA under CLP Regulation is displayed under this section. Chemical structure of fatty acids (13–15). Get medical attention. J.A. Sebacic dihydrazide. For example, poly(ethylene terephthalate-co-butylene terephthalate-co-ethylene adipate-co-butylene adipate) (PET-co-PBT-co-PEA-co-PBA) copolyesters, due to their resemblance to the homologous PBT-co-PBA in terms of physical and mechanical properties were suggested for similar applications as the latter copolymer, namely as films for agriculture and household products, or as a hydrophobic-protecting coating for food containers [60,113]. Hence, the synthetic approach used to prepare UPRs can be performed in three steps [34,63,64]. Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, as processing aid, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, manufacturing of the substance and formulation in materials. The purpose of the information provided under this section is to highlight the substance hazardousness in a readable format. Sebacic acid; Decanedioic acid. The Global Sebacic Acid Market will grow by USD 129.57 mn during 2020-2024 In its pure state it is a white flake or powdered crystal.Sebacic acid is produced from castor oil by using sodium hydroxide, sulfuric acid with catalysts including zinc oxide and phenol.In the industrial setting, sebacic acid and its The source of the information is mentioned in the introductory sentence of the hazard statements. Precautionary statements - describe recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product or improper storage or handling of a hazardous product. SEBACIC ACID 97AN39ICTC Overview Structure Names 7: Classification 1: Identifiers 10: Relationships 2: Active Moiety 1: Notes 1: Audit Info References 17: Moieties 1: Substance Class: Chemical Record UNII: 97AN39ICTC.