Availability diterpenes from Tinospora rumphii. Uses (Phytomedicine, April 2010: Beneficial effects of beta-Ecdysone on the joint, epiphyseal cartilage tissue and trabecular bone in ovariectomized rats). (41) Commercially extracted Makabuhay (Tinospora cordifolia) oil extract called Guduchi can also be bought in most health stores specializing in Ayurveda. Distribution (14) Botany Boerl. (74) on affected areas. T. crispa also showed dose-dependent antiproliferative activity against many types of cancer cells. Somehow, scientific studies which are made on medicinal uses of Makabuhay (Tinospora rumphii Boerl) are limited to animals or in the test tube. Tinospora thorelii Gagnep. Makabuhay is a Filipino translation of the English term ‘pro-life or to give life’. It is commonly known as the paliahan in the Visayas region. Makabuhay herbal medicine is generally for topical application and moderate intake. EVALUATION OF ANALGESIC AND ANTIMICROBIAL ACTIVITY OF DIFFERENT FRACTIONS OF CRUDE METHANOL EXTRACT OF TINOSPORA CRISPA STEM. Studies found that Ixora (Santan) promotes wound healing with antimicrobial potentials. New applications short pedicelled. Makabuhay (Tinospora rumphii Boerl) contains many chemicals that are known to have an antioxidant activity while few can even fight cancer cells in animal’s study. ), promotes wound healing and alleviate skin itching. (43) Results suggest the mechanisms of underlying hepatotoxicity of T. crispa are the same as those encountered with furanoditerpenoids-containing plants i.e., Teucrium chamaedrys or Dioscorea bulbifera. Ang makabuhay ay isang gumagapang na halaman na maaaring may taas na 4 hanggang 10 metro. (69) Results showed improvement in lipid profile (decreased total cholesterol, triglycerides, LDL, and increased HDL). Results showed dose-dependent anti-malarial effect. Results showed cell viability decreased in a dose dependent manner in each cells similar to the patter of tamoxifen, with lowest IC50 in MCF-7. • Tinocrisposide / Chemopreventive Against Human Cancer Cells: Study evaluated the cytotoxic activity of tinocrisposide extract from T. crispa against human cancer cell lines (HI299 and MCF-7 cell lines). Some caution use by patients with cardiac disorders. They are a rich source of calcium and iron. In the study, liver damage during malarial infection was evidenced by significant (p<0.05) increase in AST and ALT with markedly increased albumin. The study used • Used for fertility regulation. Borapetoside C from Tinospora crispa improves insulin sensitivity in diabetic mice. • Anti-MRSA Activity / No Synergism with S. mahagoni: Study showed the extracts of T. crispa and S. mahagoni were effective against MRSA (methicillin-resistant Staphylococcus aureus) strains. and chop 1/2 glass of stem. Tinospora cordifolia. According to results, the Glut-4 and the dominant protein were modulated by Tinospora cordifolia, Moreover, the uptake of glucose was likewise mediated suggesting the anti-diabetic properties of TC compounds. The ex vivo study showed significant effect on aminopyrine N-demethylase activity. Silymarin or Milk Thistle is still best for liver protective activity against toxins that can cause liver damage. (7) Of fourteen studied plants, the highest inhibition activity to alpha-glucosidase was shown by BWA65 found from Tinospora crispa. Makabuhay might affect blood sugar levels, so there is a concern that it might interfere with blood sugar control during and after surgery. Makabuhay (Tinospora cordifolia) or Guduchi is a popular Ayurveda medicinal plant, also called Heavenly elixir or divine nectar, widely used to promote overall health. - Occurs in Malaya. Makabuhay is a climbing, dioecious vine reaching (27) Folkloric The articles contained herein are for entertainment and informational purposes only. relieving symptoms of hay fever or allergic rhinitis. The roots, branches and leaves are harvested and used (see below for preparations). • Tinospora crispa Ointment Against Head Lice / Pediculus humanus capitis: Study evaluated the safety, efficacy, and physiochemical characteristics of T. crispa pediculicidal ointment. The high antioxidant activity was attributed to apigenin and magnoflorine. It differs from two previously reported cases of chronic intake of powdered dry stems in pellet and tablet formulations. Furanoid diterpene glucosides from Tinospora rumphii, Clerodane Diterpenes from Tinospora rumphii, The use of 25% fresh makabuhay (Tinospora rumphii Boerl) vine decoction as preventive medication for swine (Sus domesticus) suckling diarrhea (15-35 days old), The modulation of ovarian 3B-Hydroxysteroid dehydrogenase activity in rats during treatment with Tinospora rumphii Boerl, Hypoglycaemic and hypolipidaemic action of alcohol extract of Tinospora cordifolia roots in chemical induced diabetes in rats, New antimicrobial diterpenes from Tinospora rumphii, Tinospora crispa (L.) Hook. • Wound Healing / Stem: Study evaluated the effect of Tinospora crispa on wound healing in diabetic albino mice given intraperitoneally and with local ointment application. Results showed no antidiabetic benefit. • Used Preparation of ointment: Wash Scientific Name: Tinospora cordifolia (Journal of Ethnopharmacology. Study suggests the two triterpenes produced mild cardiotonic effects. Antifungal compounds were identified as hexadecanoic acid and 9,12-octadecadiernoic acid. Kamias has their own name in every country. Decoction of stem used as vulnerary for itches, ordinary and cancerous wounds. • A study showed that the bitter extract of the stem does not Properties (31) • In Thailand, wood decoction used for diabetes, fever and to reduce thirst; also used as appetizer. • Herb-Drug Interaction / Effect of T. crispa on Drug Metabolism in Rat Liver: Study investigated the in vitro and ex vivo effects of crude extract and various solvent extracts of stem of T. crispa on aminopyrine N-demethylase activity in Sprague-Dawley rat liver. An ethanolic extract at dose of 100 and 200 g/200gbwsignificantly reduced blood ALT and AST, along with number of pyknotic nuclei, karyorrhexic nuclei and karyolysis nuclei lower than negative control. (47) • Enhancement of Glucose Transport: Study evaluated the effect of water-ethanol extract of T. crispa on glucose transporter (GLUT1 and GLUT4) and AMPK alpha1 and PPAR gamma expression. • Preparation with coconut oil use as cure for rheumatism; also for flatulence (kabag) in children. Tinospora crispa contains natural insulin enhancer and possesses antiproliferative effects. An alternative is the use of brotowali (T. crispa). January 2005: Efficacy of Tinospora cordifolia in allergic rhinitis), The Division of Endocrinology, University of Göttingen in Germany conducted a laboratory investigation on the effects of beta-Ecdysone (ECD), a steroid found in Tinospora cordifolia extract on joints, epiphyseal cartilage and trabecular tissues in rats. - Being studied for it possible stimulant effect on the immune system. (33) (82) (19) Established 2015. wash, or crush stem, soak in oil for 12 hours and apply oil extract f. & Thomson: Makabuhay (Tag., Ilk.) Stem extract showed high antioxidant activity in the following order: DPPH > reducing power > metal chelating,98.8%, 0.957, 81.97%, respectively. • The basis of a popular preparation used as cordial, tonic, or ingredient in cocktails. Results showed potential benefits as remedy for diabetic wound healing, possibly through reduction of blood glucose level and prevention of microbial infection in the affected area. (72) Cinnanomum is one of the oldest herbal medicines known, mentioned in China medicinal texts as far back as 4,000 years ago and used medicinally in Egypt around 500 BC. - Wild-crafted. Results showed the extract had relative therapeutic effect with glibencladmise as standard drug. • Makabuhay, with madre de cacao and hot red pepper extract in of boiling water). Makabuhay has yellow flowers, growing in lax racemes from nodes on old wood. A study in the Indira Ghandi Medical College showed it effective in Crush leaves applied to wound and made into dressing for itches. Decoction of stem used to wash aching eyes and syphilitic sores. Recent uses and preparations Common name: Makabuhay (Tagalog); Heavenly elixir (Ingles) Image Source: kalusugan.ph. Fraction 1 showed antifungal activity against C. albicans with inhibitory potential of 27.73 ± 0.16%. Findings showed T. crispa had higher antioxidant potential than ascorbic acid. The Significance of Tinospora crispa in Treatment of Diabetes Mellitus. Maka-Agham na Kawanggawa para sa Kalinangan ng Buhay, Inc. The insulinotropic effect was also evident in perfused human and rat islets and HIT-T5 B cells. Also contains a amorphous bitter principle, picroretine and Results suggest T. crispa has potential as an anticancer agent via targeting insulin-like growth factor system and insulin signaling pathway in HepG2 cancer cell line. Results showed significant lowering of plasma glucose levels in normal and STZ-induced type 1 diabetic mice. An ethanol extract showed maximum inhibition against growth of Candida albicans. 100 gms of the vine in small pieces, mix with 3 ounces of coconut oil. The extract administered intraperitoneally exhibited significant (p<0.05) antinociceptive and anti-inflammatory activities in a dose-dependent manner in all assays used. However, the combination of the two plants showed no synergism against MRSA strains. • Lipid-Lowering / Anti-Atherosclerotic: Study evaluated the hypocholesterolemic and anti-atherosclerotic properties of T. cripa aqueous extract on hyperlipidemic rabbits for 10 weeks. Crude extract and fraction showed no significant antimicrobial activity. Antibacterial activity were done by disc diffusion and broth dilution methods against clinical isolates of 8 MRSA and S. aureus ATCC strain. Guyabano belongs to the family of Annonaceae, (A. muricata L.). A spoonful of dried leaves and thinly chopped stems are boiled in a cup of water. (32) • Effect on Blood Pressure and Heart Rate / Stems: Study evaluated the effects and mechanism of action of an n-butanol extract of stems on blood pressure and heart rate in anesthetized rats. The AE showed mortality at 4 g/kg. • Antiproliferative / Triple Negative Breast Cancer Cell Lines: Study of T. crispa methanol extract showed antiproliferative effect on triple negative breast cancer cells with less toxicity to the normal breast cells. The addition of the ointment did not significantly contribute to wound healing with regards wound healing time and percent wound contraction. (63) • Pounded stem, mixed with coconut oil, has been used for a variety • Swine Diarrhea Control: Study showed reduction of diarrhea with use of 25% fresh makabuhay decoction from day 15-35 in piglets with diarrhea. New antimicrobial contain an alkaloid. • Mechanisms of Anti-Hyperglycemic Action / Review: The mechanisms of anti-hyperglycemic actions are due to stimulation of insulin secretion, enhancement of glucose utilization in peripheral tissues and reduction of hepatic gluconeogenesis. • Thrombolytic Activity / Gelam Honey Mixture: Study evaluated a methanol extract of stems of T. crispa for thrombolytic (in vitro clot lysis) and cytotoxic (brine shrimp lethality bioassay) activities. (29) • Scabies: Crush fresh stem and apply juice over the affected. It is a common vegetable found in the market. The end-product is a dark-brown tablet with a coffee-like aromatic odor, slightly bitter tasting, containing 500 mg of lyophilized makabuhay stem aqueous extract. intelligence and prevent disease. (56) Results showed lowering of total cholesterol, triglyceride, LDL-C while HDL level was elevated. This traditional medicine is native to Sri Lanka and Southeast … Makabuhay plant has succulent bark that is creamy white to grey in colour; it has deep clefts spotted with lenticels. (48) • Study of stems yielded four new furanoid diterpenes of clerodane types, Crispene A, B, C, and D, including one known furanoid diterpene glucoside, borapetoside E. (66) Results suggest supplementation with T. crispa extract of 450 mg/kg might reduce or retard progression of atherosclerotic plaque development induced by dietary cholesterol. (15) (11) The study suggests that Tinospora cordifolia has antiosteoporotic effects and may be of value in the prevention and treatment of osteoporosis and osteoarthritis which is of increasing importance due to aging and obesity among individuals. (www.prevention.com) Place in bottle and "cook" under the sun for 5-7 days. f. & Thomson is an accepted name. It's ironic because the first time I encountered this plant, I was told that this can cause abortion for … • Hypoglycemic in Metabolic Syndrome / Dry Powder Stem: Randomized double-blind placebo-controlled crossover design evaluated T. crispa dry powder in patients with metabolic syndrome. Makabuhay poultice is used to treat gout, arthritis, and rheumatism by reducing pain and edema. use of Tinospora rhumhii. (see study below) (28) Cut (35) Study evaluated a methanol and chloroform extract of stems of T. crispa for healing efficiency on excision wound model in albino rats. • Phytoconstituents of Solvent Extracts / Antibacterial / Stem: Hexane extract yielded alkaloids, flavonon, polyphenol substances and steroid type saponins; chloroform extract yielded alkaloids and triterpenoid type saponins; butanol extract yielded alkaloids, flavon, and polyphenol substances; aqueous extract yielded free acid and steroid type saponins; methanol extract yielded alkaloids, tanins, and triterpenoid type saponins. a bitter principle, colombine (2.22%); traces of an alkaloid; and a (Makabuhay) in the Treatment of Scabies, Insecticidal • Clerodane Diterpenes: Study yielded two new diterpenes (1 and 2) from the leaves of Tinospora rumphii, along with known compounds tinotufolin D and vitexilactone. (eCAM 2011: Radiation-induced Testicular Injury and its Amelioration by Tinospora Cordifolia Extract), The Division of Ethnopharmacology of Loyola College in India conducted a study on the effects of Tinospora cordifolia extracts against induced hepatocellular carcinoma (HCC) in rats to determine its potential use in cancer therapy. The reduction in parasitemia degree of 3D7 strain suggests a potential candidate as antimalarial. The antiatherogenic effect could be due to enhanced serum HDL, increase antioxidant status and flavonoid composition. Diabetes. Lagundi (scientific name: Vitex negundo) is a shrub that grows in the Philippines.It is one of the ten herbal medicines endorsed by the Philippine Department of Health as an effective herbal medicine with proven therapeutic value. The process involves culture medium inoculation, crushing and drying of fresh stems, fermentation. • Anti-scabies: Tinospora rumphii The plant belongs to the family of Menispermaceae, and can grow, or rather climb, up to fifteen meters long. The stem extract of T. crispa was the most effective on lowering blood glucose via increase of serum insulin. rumphii Boerl. (58) Makabuhai (Tag., Bis., Ilk.) • • Mechanism of Apoptosis in Hepatoma G2 Cell Lines: Hepatoma G2 (HepG2) cell line proliferation is controlled by insulin-like growth factor (IGF) signaling system. Stay on the safe side and avoid use. • Aqueous extract used for treatment of stomach trouble, indigestion, and diarrhea. Powered by Create your own unique website with customizable templates. Gen info - Revised taxonomy: The genus Plumeria of the Apocynaceae family was revised to contain P. rubra, P. obtusa, and their hybrids.Plumeria acuminata, P. acutifolia, and P. lutea, previously species names, are now recognized as botanical forms of P. T. crispa exhibited an immunomodulatory effect through stimulation of INF-γ, IL-6, and IL-8 expressions. Caution is advised with long-term extract use at doses equal to or greater than 500 mg/kg because it can significantly elevate ALT level. Infusion of stem drunk as vermifuge. Study in mice showed T. crispa extract exhibited hepatoprotective effect during malarial infection. Cold infusion of seed used to treat various illnesses from arthritis to treatment of T2DM, suggests! Branches and leaves are very sensitive, both pinnae and leaflets, folding when touched arthritis, and the in... Of protein denaturation control while DMSO was negative control, Ilk.: Akar patawali, Akar,... 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